Riding the Dragon :)

BERNADETTE: Howie , the estrogen is getting absorbed by your skin . That's why you've been all bloated and moody and a giant pain in the ass!
HOWARD: But you're full of estrogen and you don't act like that !

BERNADETTE: That's because I'm a woman. I've had years of practice riding the dragon.

The Big Bang Theory - Series 07 Episode 02